Research Group

Principal Investigator

Rania Siam

2002 - 2003: Postdoctoral Fellow. The Salk Institute for Biological Studies, La Jolla, CA. Molecular and Cell Biology Laboratory
2001: Postdoctoral Fellow. The Scripps Research Institute, La Jolla, CA, Molecular and Experimental Medicine 
2001: PhD McGill University, Montreal, Canada. Microbiology and Immunology
1993: MBBCH. Ain Shams University, Faculty of Medicine, Cairo, Egypt

Research Assistants

Amged Ouf

Genomic Specialist

2000: B.Sc. (Biochemistry, Science) Ain Shams University

Mohamed, Yasmine M., Mohamed A. Ghazy, Ahmed Sayed, Amged Ouf, Hamza El-Dorry, and Rania Siam. "Isolation and characterization of a heavy metal-resistant, thermophilic esterase from a Red Sea Brine Pool." Scientific reports 3 (2013).

Sayed A, Ghazy MA, Ferreira AJ, Setubal JC, Chambergo FS, Ouf A, Adel M, Dawe AS, Archer JA, Bajic VB. 2013. A novel mercuric reductase from the unique deep brine environment of Atlantis II in the Red Sea. Journal of Biological Chemistry:jbc. M113. 493429.

Ahmed El Hosseiny​

Bioinformatics Analyst, Biology Department

2010: Diploma (Bioinformatics) Information Technology, Information Technology Institute (ITI)

2007: B.Sc. (Biotechnology) Agricultural Sciences (English Section), Faculty of Agriculture, Cairo University, Egypt

MSc Students

Noha A. Attalah

Current research project: Characterization of a novel DNA ligase LigATII from the Red Sea, Atlantis II Deep Brine Pool

2014: Postgraduate Diploma (Biotechnology / Pharmacy), Cairo University.

2010: B.Sc. (Pharmaceutical Sciences), Cairo university.

Sherry Kamal Aziz

Current Research Project: Analysis of sediments only viruses in Red Sea brine pools.

2012: BSc (Pharmacy) Ain Shams University.

PhD Students

Mohamed N. Malash

Current research project: Detection and characterization of novel extremophilic peptidoglycan hydrolases in metagenomes of hydrothermal vents.

2009: M.Sc. Genetic Engineering and Biotechnology: Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute (GEBRI), Menofia University – Sadat city, Egypt


S.H. Hassanein, M.I. Nasr, R.M. Abd El-Aziz, A.F. Elbaz, and M.N. Malash (2009) Induction of Cephalosporin C inCephalosporium acremonium Using U.V. Light and Selection of a Mutant that Showed Highest Fermentation Capability. Minufiya J. Agric. Res. 34(1):35-55

A.M. Michael and M.N. Malash (2015) A Validated Assay of Urease Enzyme in Different Sources Using Silver Nanoparticles. Food Anal. Methods. 8(10):2482-2486 (DOI: 10.1007/s12161-015-0139-1)

Nahla Hussein

Current Research Project: Identification of surface exposed lipoproteins in E.coli and of the export machinery.

2013: MSc (Biotechnology) The American University in Cairo
Title of thesis: “Mutational Analysis of the Intrinsically Disordered N- terminal Linker Domain of the Stress Sensor RcsF in E. coli K-12”

2013: MSc (Biochemistry/Pharmaceutical Sciences) Cairo University
Title of thesis: “Molecular Cloning of a Gene Coding for an Immunogenic Protein from the Cattle Ticks Boophilus annulatus Salivary Glands”

2004: BSc (Pharmacy) Cairo University


Y.E. Shahein, M.T.A.E.- Rahim, N.A. Hussein, R.R. Hamed, A.E.E.- Hakim, M.M. Barakat. Molecular cloning of a small Heat Shock Protein (sHSPII) from the cattle tick Rhipicephalus (Boophilus) annulatus salivary gland, International Journal of Biological Macromolecules, 47, (2010), 614 – 622.

Sarah Sonbol

Current research project: Metagenomic analysis of integrons in Siwa water samples

2014: MSc (Biotechnology) AUC 

Title of Thesis: “Cloning, expression and preliminary characterization of a novel nitrilase from the Red Sea, Atlantis II Deep Brine pool using a metagenomic approach”

2007: BSc (Pharmacy) Ain Shams University


Sonbol S, Ferreira AJ, Siam R, 2015. A novel nitrilase isolated from the Red Sea Atlantis II brine pool with unique thermostability profile and selected heavy metal tolerance. BMC Biotechnology, submitted

Laila Ziko

Current research project: Mining for Novel Anticancer Polyketide Synthases and Non-Ribosomal Peptide Synthases from the Red Sea Brine Pools.

2013: MSc (Biotechnology) The American University in Cairo.

Thesis title: "Triple trouble: examining the effect of combining mechanical stress, PBMCs and cisplatin on HepG2 cell death"

2008: BSc. (Pharmacy & Biotechnology) The German University in Cairo.


Ziko L, Riad S, Amer M, Zdero R, Bougherara H, Amleh A. Mechanical stress promotes cisplatin-induced hepatocellular carcinoma cell death. Biomed Res Int. 2015;2015:430569. doi: 10.1155/2015/430569. Epub 2015 Jan 22.