EDUCATION
1962-1966 Alexandria University, Alexandria, Egypt, B.Sc. (Faculty of Agriculture; Pesticides Chemistry and Toxicology).
1968-1972 Department of Biochemistry, Institute of Chemistry, University of São Paulo, Ph.D. (Biochemistry).
1978 Department of Biochemistry, Institute of Chemistry, University of São Paulo, Brazil, Habilitation in Biochemistry and Molecular Biology.
PROFESSIONAL CAREER
2006 Professor and Chair, Department of Biology, The American University in Cairo, Cairo, Egypt.
1997-2006 Professor of Biochemistry and Molecular Biology, Department of Biochemistry, Institute of Chemistry, University of São Paulo, Brazil.
1990-1997 Associate Professor of Biochemistry, Department of Biochemistry, Institute of Chemistry, University of São Paulo, Brazil.
1989-1990 Visiting Associate Professor, Department of Biochemistry, Cornell University Medical College, New York, NY, USA, (total of 2 years).
1983-1989 Associate Professor of Biochemistry, Department of Biochemistry, Institute of Chemistry, University of São Paulo, Brazil.
1979-1982 Assistant Professor of Biochemistry, Department of Biochemistry, Cornell University Medical College, New York, NY, USA, (total of 3 years).
1974-1977 Postdoctoral Fellow, Department of Physiological Chemistry, Roche Institute of Molecular Biology, Nutley, NJ, USA, (total of 3 years).
1972-1974 Instructor, Department of Biochemistry, Institute of Chemistry, University of São Paulo, Brazil.
TEACHING
Over the last 30 years I taught the following courses: in the undergraduate program: Biochemistry; Molecular Biology; introductory course in Molecular Biology of the Genes.
In the graduate program: Advance Molecular Biology; Structure and Function of Enzymes; Protein Chemistry; Biotechnology.
RESEARCH INTERST
Enzymology and the regulation of metabolic pathways; Regulation of gene expression; Structural and functional genomics.
THESIS ADVISOR AND FINANCIAL SUPPORT
I have so far served as the thesis advisor for four M.Sc. and 11 Ph.D. students, and as the mentor for 7 post-doctoral fellows.
I have obtained financial support as principal investigator from major funding institutions in Brazil, Ludwig Institute for Cancer Research, the United States Department of Agriculture (USDA) and the World Bank.
AWARDS
Mellon foundation, Cardiovascular Center Mellon Scholar in Basic Medical Sciences (1979-1982).
Scientific and Technological merit award of the Government of the State of Sao Paulo (2002). "Mérito Científico e Tecnológico do Governo do Estado de São Paulo."
PUBLICATION LIST
Nene et al., Genome sequence of Aedes aegypti, a major arbovirus vector. Science 5832 (2007) 1718-1723.
Ferreira Junior JR, Ramos AS, Chambergo FS, Stambuk BU, Muschellack LK, Schumacher R, El-Dorry H. Functional expression of the maize mitochondrial URF13 down-regulates galactose-induced GAL1 gene expression in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communication 339 (2006) 30-36.
Eric D. Bonaccorsi, Ari J. S. Ferreira, Felipe S. Chambergo, Augusto S. P. Ramos, Marluce C. Mantovani, João P. Simon Farah, Cristina S. Sorio, Andreas K. Gombert, Aldo Tonso and Hamza El-Dorry. Transcriptional response of the obligatory aerobe Trichoderma reesei to hypoxia and transient anoxia: implications for energy production and survival in the absence of oxygen. Biochemistry 45 (2006) 3912-3924.
Ramos, A. S., Chambergo, F. S., Bonaccorsi, E. D., Ferreira, A. J., Cella, N.,Gombert, A. K., Tonso, A. A Oxygen- and glucose-dependent expression of Trhxt1, a putative glucose transporter gene of Trichoderma reesei. Biochemistry 45 (2006) 8184-8192.
Nascimento et al., Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis. Journal of Bacteriology 186 (2004) 2164-2172.
Monteiro-Vitorello et al., The genome sequence of the gram-positive sugarcane pathogen Leifsonia xyli subsp. Xyli. Mol Plant Microbe Interact.17 (2004) 827-836.
Koide et al., DNA microarray-based genome comparison of a pathogenic and a nonpathogenic strain of Xylella fastidiosa delineates genes important for bacterial virulence. Journal of Bacteriology 186 (2004) 5442-5449.
Reis et al., Antisense intronic non-coding RNA levels correlate to the degree of tumor differentiation in prostate cancer. Oncogene 23 (2004) 6684-6682.
Brentani et al., The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags. Proceedings of the National Academy of Sciences of the United States of America 100: (2003) 13418-13423.
Van Sluys et al., Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosa. Journa of Bacteriology 185 (2003) 1018-1026.
Da Silva et al., Comparison of the genomes of two Xanthomonas pathogens with differing host specificities. Nature 417 (2002) 459-463
Chambergo F. S., Bonaccorsi E. D., Ferreira A. J., Ramos A. S., Ferreira J. R. Junior, Abrahao-Neto J., Farah J. P., El-Dorry H.: Elucidation of the metabolic fate of glucose in the filamentous fungus Trichoderma reesei using expressed sequence tag (EST) analysis and cDNA microarrays. Journal of Biological Chemistry 277(2002) 13983-13988.
Camargo et al., The contribution of 700,000 “ORF sequence tags” to the definition of the human transcriptome. Proceedings of the National Academy of Sciences of the United States of America 98 (2001) 12103-12108
Leite A., Kemper, E., Silva, M., Luchessi, A., Siloto, R., Bonaccorsi, E., El-Dorry, H. & Arruda, P.: Expression of correctly processed human growth hormone in seeds of transgenic tobacco plants. Molecular Breeding 6 (2000) 47-53.
Simpson et al., The genome sequence of the plant pathogen Xylella fastidiosa. Nature 406 (2000) 151-157.
Leite A., Kemper, E., Silva, M., Luchessi, A., Siloto, R., Bonaccorsi, E., El-Dorry, H. & Arruda, P.: Expression of correctly processed human growth hormone in seeds of transgenic tobacco plants. Molecular Breeding 6 (2000) 47-53.
de Souza et al., Identification of human chromosome 22 transcribed sequences with ORF expressed sequence tags. Proceedings of the National Academy of Sciences of the United States of America 97 (2000) 12690-12693.
Simpson et al., The genome sequence of the plant pathogen Xylella fastidiosa. Nature 406 (2000) 151-157.
Carraro, D.M., Ferreira Junior, J.R., Schumacher, R., Pereira, G.G., Hollenberg, C.P. and El-Dorry, H.: A region of the cellobiohydrolase I promoter from the filamentous fungus Trichoderma reesei mediates glucose repression in Saccharomyces cerevisiae, dependent on mitochondrial activity. Biochemical & Biophysical Research Communications 253 (1998) 407-414.
Carle-Urioste, J.C., Escobar-Vera, J., El-Gogary, S., Henrique-Silva, F., Torigoi, E., Crivellaro, O., Herrera-Estrella, A. and El-Dorry, H.: Cellulase induction in Trichoderma reesei by cellulose requires its own basal expression. Journal of Biological Chemistry 272 (1997) 10169-10174.
272 (1997) 10169-10174.
El-Dorry, H., Crivellaro, O., Leite, A., Abrahão-Neto, J., Henrique-Silva, F., Escobar-Vera, J., Matheucci Junior, E., Carle-Urioste, J.C., Pereira, G.G., Carraro-Pereira, D.M. and El-Gogary, S.: Transcriptional control of the cellulase genes in Trichoderma reesei. Brazilian Journal of Medical & Biological Research 29 (1996) 905-909.
Henrique-Silva, F., El-Gogary, S., Urioste, J., Matheucci, E., Crivellaro, O. and El-Dorry, H.: Two regulatory regions controlling basal and cellulose-induced expression of the gene encoding cellobiohydrolase I of Trichoderma reesei are adjacent to its TATA box. Biochemical & Biophysical Research Communications 228 (1996) 229-237.
Torigoi, E., Henrique-Silva, F., Escobar-Vera, J., Carle-Urioste, J.C., Crivellaro, O., El-Dorry, H. and El-Gogary, S.: Mutants of Trichoderma reesei are defective in cellulose induction, but not basal expression of cellulase-encoding genes. Gene 173 (1996) 199-203.
Abrahão-Neto, J., Rossini, C., El-Gogary, S., Henrique-Silva, F., Crivellaro, O. and El-Dorry, H.: Mitochondrial functions mediate cellulase gene expression in Trichoderma reesei. Biochemistry 34 (1995) 10456-10462.
Matheucci, E., Henrique-Silva, F., El-Gogary, S., Rossini, C., Leite, A., Vera, J., Urioste, J., Crivellaro, O. and El-Dorry, H.: Structure, organization and promoter expression of the actin-encoding gene in Trichoderma reesei. Gene 161 (1995) 103-106.
Clinton, M., Graeve, L., El-Dorry, H., Rodriguez-Boulan, E. and Horecker, B.L.: Evidence for nuclear targeting of prothymosin and parathymosin synthesized in situ. Proceedings of the National Academy of Sciences of the United States of America 88 (1991) 6608-6612.
El-Gogary, S., Leite, A., Crivellaro, O., Eveleigh, D.E. and El-Dorry, H.: Mechanism by which cellulose triggers cellobiohydrolase I gene expression in Trichoderma reesei. Proceedings of the National Academy of Sciences of the United States of America 86 (1989) 6138-6141.
Leite, A., Neto, J.A., Leyton, J.F., Crivellaro, O. and El-Dorry, H.A.: Phosphofructokinase from bumblebee flight muscle. Molecular and catalytic properties and role of the enzyme in regulation of the fructose 6-phosphate/fructose 1,6-bisphosphate cycle. Journal of Biological Chemistry 263 (1988) 17527-17533.
El-Dorry, H.A.: Purification of mRNA coding for rat-liver fructose-1,6-bisphosphatase by polysome immunoabsorption. Biochimica et Biophysica Acta 867 (1986) 252-255.
El-Dorry, H.A., MacGregor, J.S. and Soffer, R.L.: Dipeptidyl carboxypeptidase from seminal fluid resembles the pulmonary rather than the testicular isoenzyme. Biochemical & Biophysical Research Communications 115 (1983) 1096-1100
Soffer, R.L. and El-Dorry, H.A.: Angiotensin-converting enzyme: immunologic, structural, and developmental aspects. Federation Proceedings 42 (1983) 2735-2739.
El-Dorry, H.A., Bull, H.G., Iwata, K., Thornberry, N.A., Cordes, E.H. and Soffer, R.L.: Molecular and catalytic properties of rabbit testicular dipeptidyl carboxypeptidase. Journal of Biological Chemistry 257 (1982) 14128-14133.
Iwata, K., Lai, C.Y., El-Dorry, H.A. and Soffer, R.L.: The NH2- and COOH-terminal sequences of the angiotensin-converting enzyme isozymes from rabbit lung and testis. Biochemical & Biophysical Research Communications 107 (1982) 1097-1103.
El-Dorry, H.A. and MacGregor, J.S.: Rat and rabbit liver mRNAs code for fructose 1,6-bisphosphatases that differ in molecular weight. Biochemical & Biophysical Research Communications 107 (1982) 1384-1389.
El-Dorry, H.A., Pickett, C.B., MacGregor, J.S. and Soffer, R.L.: Tissue-specific expression of mRNAs for dipeptidyl carboxypeptidase isoenzymes. Proceedings of the National Academy of Sciences of the United States of America 79 (1982) 4295-4297.
Schettino, C.M., Lima, D.F., Leyton, J.F., El-Dorry, H.A. and Bacila, M.: Studies on the structure of aldolase A from chicken muscle. Biochimica et Biophysica Acta 667 (1981) 411-420.
Leyton, J.F., Chinelatto, A.M., El-Dorry, H.A. and Bacila, M.: Correlation of inhibition of fructose 1,6-bisphosphatase by AMP and the presence of the nucleotide-binding domain. Archives of Biochemistry & Biophysics 202 (1980) 168-171.
Cruz, Z.M., Tanizaki, M.M., El-Dorry, H.A. and Bacila, M.: On the nucleotide binding domain of fructose-1,6-bisphosphatase. Archives of Biochemistry & Biophysics 198 (1979) 424-433.
Horecker, B. L., El-Dorry, H. A., Botelho, L., Sun, S., Chu, D., Lazo, P., Crivellaro, O., Tsolas, O., Macgregor, J. S. & Pontremoli, S. (1979). Limited proteolysis of fructose 1,6-bisphosphatase. In Limited Proteolysis in Microrganisms, (Cohen, G. N. and Holzer, H. eds), DHEW Publication no. (NIH) 79-1591, p. 5.
de Faria, J.B., El-Dorry, H.A. and Bacila, M.: Multiple forms of phosphofructokinase in developing rabbit and guinea pig tissues. Developmental Biology 65 (1978) 547-552.
Pontremoli, S., Melloni, E., Salamino, F., Michetti, M., Botelho, L.H., El-Dorry, H.A., Chu, D.K., Isaacs, C.E. and Horecker, B.L.: Origin of tryptophan in fructose 1,6-bisphosphatase purified from livers of fed rabbits. Archives of Biochemistry & Biophysics 191 (1978) 825-827.
El-Dorry, H.A. and Bacila, M.: Purification and properties of rabbit heart muscle aldolase. Biochimica et Biophysica Acta 480 (1977) 305-314.
Botelho, L.H., El-Dorry, H.A., Crivellaro, O., Chu, D.K., Pontremoli, S. and Horecker, B.L.: Digestion of rabbit liver fructose 1,6-bisphosphatase with subtilisin: sites of cleavage and activity of the modified enzyme. Archives of Biochemistry & Biophysics 184 (1977) 535-545.
El-Dorry, H.A., Chu, D.K., Dzugaj, A., Botelho, L.H., Pontremoli, S. and Horecker, B.L.: Primary structure of the S-peptide formed by digestion of rabbit liver fructose 1,6-biphosphatase with subtilisin. Archives of Biochemistry & Biophysics 182 (1977) 763-773.
El-Dorry, H.A., Chu, D.K., Dzugaj, A., Tsolas, O., Pontremoli, S. and Horecker, B.L.: Rabbit liver fructose 1,6-bisphosphatase: the sequence of the amino-terminal region. Archives of Biochemistry & Biophysics 178 (1977) 200-207.
Dzugaj, A., Chu, D.K., El-Dorry, H.A. and Horecker, B.L.: Isolation of the S-peptide formed on digestion of fructose 1,6-bisphosphatase with subtilisin and its non-covalent association with the enzyme protein. Biochemical & Biophysical Research Communications 70 (1976) 638-646.
El-Dorry, H.F., Medina, H. and Bacila, M.: Interference of phenothiazine compounds in the colorimetric determination of inorganic phosphate. Analytical Biochemistry 47 (1972) 329-336.
Patents
Processo para melhoramento da produção de celulases através da aceleração da indução dos transcritos de celobiohidrolase I (cbh1) e endoglucanase I (egl1) em fungos celulolíticos. (1992), Instituto Nacional da Propriedade Industrial No. 9.202.983 (Brazil).
Desenvolvimento de um cassete específico para a expressão de proteínas heterólogas em sementes de plantas transgênicas. (1999), Instituto Nacional da Propriedade Industrial. No. PI9805166 (Brazil).
Xylella DNA sequences and uses thereof (2000) United States Patent and Trademark Office No. 00/07442-9 (USA).
Elemento regulador que active la expresion gênica em condiciones da baja tension de oxigeno y represionpor glucosa y aplicacione. (2002), Oficina Española de Patentes y Marcas Oficina Española de Patentes y Marcas No. S2200705 (Spain).